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Dengue virus (DENV) causes a range of symptoms from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Repeat infections with DENV are associated with severe DHF. Determination of dengue serotypes in current and previous epidemics will be crucial in being able to predict the severity of the current epidemics and for monitoring the predominant serotypes as a warning to a potential dengue outbreak.
The new assay “NS1-Serotyping-ELISA” was developed to detect the NS1 protein and identify DENV serotypes simultaneously. It offers an alternative to the current method of identifying DENV serotypes through laborious virus isolation followed by immunofluorescent assay and sophisticated RT-PCR.
This technology is available for licensing or further R&D collaboration. For further information, please contact NSTDA Technology Licensing Office (TLO).
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